Alternative mutational architectures producing identical M -matrices can lead to different patterns of evolutionary divergence.

ABSTRACT: Explaining macroevolutionary divergence in light of population genetics requires understanding the extent to which the patterns of mutational input contribute to long-term trends. In the context of quantitative traits, mutational input is typically described by the mutational variance-covariance matrix, or the M -matrix, which summarizes phenotypic variances and covariances introduced by new mutations per generation. However, as a summary statistic, the M -matrix does not fully capture all the relevant information from the underlying mutational architecture, and there exist infinitely many possible underlying mutational architectures that give rise to the same M -matrix. Using individual-based simulations, we demonstrate mutational architectures that produce the same M -matrix can lead to

SUBMITTER: Jiang D 

PROVIDER: S-EPMC11642737 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature