Polyfunctional IL-21⁺ IFNG⁺ T follicular helper cells contribute to checkpoint inhibitor diabetes mellitus and can be targeted by JAK inhibitor therapy.

ABSTRACT: Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, but their use is limited by the development of autoimmunity in healthy tissues as a side effect of treatment. Such immune-related adverse events (IrAE) contribute to hospitalizations, cancer treatment interruption and even premature death. ICI-induced autoimmune diabetes mellitus (ICI-T1DM) is a life-threatening IrAE that presents with rapid pancreatic beta-islet cell destruction leading to hyperglycemia and life-long insulin dependence. While prior reports have focused on CD8⁺ T cells, the role for CD4⁺ T cells in ICI-T1DM is less understood. Here, we identify expansion CD4⁺ T follicular helper (Tfh) cells expressing interleukin 21 (IL-21) and interferon gamma (IFNG) as a hallmark of IC

SUBMITTER: Huang N 

PROVIDER: S-EPMC11642801 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature