When most fMRI connectivity cannot be detected: Insights from time course reliability.

ABSTRACT: The level of correlation between two phenomena is limited by the accuracy at which these phenomena are measured. Despite numerous group reliability studies, the strength of the fMRI connectivity that can be detected given the within-subject time course reliability remains elusive. Moreover, it is unclear how within-subject time course reliability limits the robust detection of connectivity on the group level. We estimated connectivity from a working memory task. The grand mean connectivity of the connectome equaled r = 0.41 (95% CI 0.31-0.50) for the test run and r = 0.40 (95% CI 0.29-0.49) for the retest run. The mean connectivity decreased to r = 0.09 (95% CI 0.03-0.16) when test-retest reliability and auto-correlations of single time courses were considered, indicating that less than a

SUBMITTER: Koten JW 

PROVIDER: S-EPMC11642907 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature