Expansion of epileptogenic networks via neuroplasticity in neural mass models.

ABSTRACT: Neuroplasticity refers to functional and structural changes in brain regions in response to healthy and pathological activity. Activity dependent plasticity induced by epileptic activity can involve healthy brain regions into the epileptogenic network by perturbing their excitation/inhibition balance. In this article, we present a new neural mass model, which accounts for neuroplasticity, for investigating the possible mechanisms underlying the epileptogenic network expansion. Our multiple-timescale model is inspired by physiological calcium-mediated synaptic plasticity and pathological extrasynaptic N-methyl-D-aspartate (NMDA) dependent plasticity dynamics. The model highlights that synaptic plasticity at excitatory connections and structural changes in the inhibitory system can transform

SUBMITTER: Koksal-Ersoz E 

PROVIDER: S-EPMC11642990 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature