Uncovering the domain language of protein functionality and cell phenotypes using DANSy.

ABSTRACT: Evolution has developed a set of principles that determine feasible domain combinations, analogous to grammar within natural languages. Treating domains as words and proteins as sentences, made up of domain words, we apply a linguistic approach to represent the human proteome as an n-gram network, which we call hereafter as Domain Architecture Network Syntax (DANSy). Combining DANSy with network theory, we explore the abstract rules of domain word combinations within the human proteome and identify connections that determine feasible protein functionality. We analyze the entropic information content of these domain word connections to establish a DANSy network that balances recovering most of proteome with n-gram complexity. Additionally, we explored subnetwork languages by focusing on rev

SUBMITTER: Shimpi AA 

PROVIDER: S-EPMC11643033 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature