Quercetin and Mesenchymal Stem Cell Metabolism: A Comparative Analysis of Young and Senescent States.

ABSTRACT: Quercetin is a natural flavonoid renowned for its potent antioxidant, anti-inflammatory, anti-diabetic, and antibacterial properties, making it a highly promising candidate for the treatment of various medical conditions. Our current study investigates the influence of quercetin on energy metabolism, fatty acid composition, oxidative stress gene expression, and sirtuin expression in early- and late-stage passages of stem cells derived from human exfoliated deciduous teeth (SHEDs). Mitochondrial respiration was analyzed by measuring oxygen consumption following a 24 h quercetin treatment, while fatty acid profiles were examined using gas chromatography-mass spectrometry (GC-MS). Additionally, quantitative PCR (qPCR) was used to assess the expression of oxidative stress genes and sirtuins. I

SUBMITTER: Ivan A 

PROVIDER: S-EPMC11643090 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature