Adverse effects of graft congestion and ameliorative effects of hepatocyte growth factor after liver transplantation in rats.

ABSTRACT: Living donor liver transplantation (LT) and deceased donor split-LT often result in congestion within liver grafts. The regenerative process and function of congested areas, especially graft congestion associated with LT, are not well understood. Therefore, we created new rat models with congested areas in partially resected livers and orthotopically transplanted these livers into syngeneic rats to observe liver regeneration and function in congested areas. This study aimed to compare liver regeneration and the function of congested areas after liver resection and LT, and to explore a new approach to ameliorate the adverse effects of graft congestion. Although the congested areas after liver resection regenerated normally on postoperative day 7, the congested areas after LT had poor regene

SUBMITTER: Aoki H 

PROVIDER: S-EPMC11643138 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature