Human genetic variation reveals FCRL3 is a lymphocyte receptor for <i>Yersinia pestis</i>.

ABSTRACT: Yersinia pestis is the gram-negative bacterium responsible for plague, one of the deadliest and most feared diseases in human history. This bacterium is known to infect phagocytic cells, such as dendritic cells and macrophages, but interactions with non-phagocytic cells of the adaptive immune system are frequently overlooked despite the importance they likely hold for human infection. To discover human genetic determinants of Y. pestis infection, we utilized nearly a thousand genetically diverse lymphoblastoid cell lines in a cellular genome-wide association study method called Hi-HOST (High-throughput Human in-vitrO Susceptibility Testing). We identified a nonsynonymous SNP, rs2282284, in Fc receptor like 3 (FCRL3) associated with bacterial invasion of host cells (p=9

SUBMITTER: Keener RM 

PROVIDER: S-EPMC11643160 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature