A 2-year calorie restriction intervention reduces glycomic biological age biomarkers.

ABSTRACT:

Background/objective

In a subset of participants from the CALERIE^™ Phase 2 study we evaluated the effects of 2y of ~25% Calorie Restriction (CR) diet on IgG N-glycosylation (GlycAge), plasma and complement C3 N-glycome as markers of aging and inflammaging.

Methods

Plasma samples from 26 participants in the CR group who completed the CALERIE2 trial and were deemed adherent to the intervention (~>10 % CR at 12 mo) were obtained from the NIA AgingResearchBiobank. Glycomic investigations using UPLC or LC-MS analyses were conducted on samples from baseline (BL), mid-intervention (12 mo) and post-intervention (24 mo), and changes resulting from the 2y CR intervention were examined. In addition, anthropometric, clinical, metabolic, DNA methylation (epigenetic) and skelet

SUBMITTER: Pribic T 

PROVIDER: S-EPMC11643172 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature