Genomic Landscape of Thrombosis Recurrence Risk Across Venous Thromboembolism Subtypes.

ABSTRACT: Venous thromboembolism (VT) is a frequent (annual incidence of 1 to 2 per 1,000) and potentially life-threatening (case-fatality rate up to 10%) disease. VT is associated with serious short-term and long-term complications including a recurrence rate of approximately 20% within five years. Anticoagulant therapy, the mainstay of VT treatment, drastically reduces the risk of early VT recurrence, but it exposes patients to a substantial risk of bleeding. We analysed the genomic architecture of VT recurrence using data from 6,571 patients across eight cohorts, 1,816 of whom experienced recurrence, with a particular focus on the clinical manifestation of the type of first VT event. Through genome-wide association studies (GWAS), we identified three loci significantly associated (P<5×10^-8</

SUBMITTER: Munsch G 

PROVIDER: S-EPMC11643180 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature