Using genomic epidemiology and geographic activity spaces to investigate tuberculosis outbreaks in Botswana.

ABSTRACT:

Background

The integration of genomic and geospatial data into infectious disease transmission analyses typically includes residential locations and excludes other activity spaces where transmission may occur (e.g. work, school, or social venues). The objective of this analysis was to explore residential as well as other activity spaces of tuberculosis (TB) outbreaks to identify potential geospatial 'hotspots' of transmission.

Methods

We analyzed data that included geospatial coordinates for residence and other activity spaces collected during 2012-2016 for the Kopanyo Study, a population-based study of TB transmission in Botswana. We included participants with results from whole genome sequencing conducted on archived samples from the original study. We used a spatia

SUBMITTER: Baker CR 

PROVIDER: S-EPMC11643207 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature