Synergism of Specific Maca Phenotypes (<i>Lepidium peruvianum</i>) in Combination with Saw Palmetto (<i>Serenoa repens</i>) Extract for Chemoprevention of Prostate Cancer as Determined in In Vitro Cytotoxicity Assays on Human Epithelial and Prostate Cancer Cells.

ABSTRACT: Selected phenotypes of dried maca (Lepidium peruvianum) hypocotyls and supercritical CO₂ extract (USPlus^®) of saw palmetto (Serenoa repens) were used to determine their targeted, cytotoxic action in prostate cancer cells. Fingerprinting by HPLC-MS and PCA analysis showed compositional differences in glucosinolates, amides, macamides, and other alkaloids, which varied based on the color and the size of hypocotyls. These phytochemical differences translated into a higher antioxidant potential of red maca than black maca samples. The greatest COX-2 inhibition was demonstrated with a combination of red maca: saw palmetto (67%:33%) and red maca: saw palmetto: black maca (25%:50%:25%). The LNCaP androgen-dependent prostate cancer cell line was the most sensiti

SUBMITTER: Gawel-Beben K 

PROVIDER: S-EPMC11643235 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature