The Elusive Biological Activity of Scorpionates: A Useful Scaffold for Cancer Therapy?

ABSTRACT: Cancer remains a formidable challenge, requiring the constant pursuit of novel therapeutic agents and strategies. Scorpionates, known for their unique coordination properties, have recently gained attention for their anticancer potential. Traditionally applied in catalysis, these compounds have demonstrated notable cytotoxicity across various cancer cell lines, often surpassing the efficacy of conventional chemotherapeutics. This review addresses recent findings on scorpionate complexes, emphasizing the impact of metal choice and ligand design on biological activity. Copper and ruthenium scorpionates show promise, leveraging redox activity and mitochondrial disruption mechanisms to selectively induce cancer cell death. Ligand modifications, including sulfur-containing heterocycles and unsu

SUBMITTER: Petrosian A 

PROVIDER: S-EPMC11643361 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature