Stereoselective Total Synthesis of Natural Decanolides Bellidisin C and Pinolidoxin.

ABSTRACT: A divergent total synthesis of bioactive, naturally occurring decanolides, pinolidoxin and bellidisin C, was accomplished by taking advantage of chiral templates L-ribose and L-malic acid. In particular, bellidisin C, which is the first total synthesis so far, was achieved through a cascade reaction of reductive elimination and nucleophilic addition in a one-pot process and a sodium-alkoxide-promoted intramolecular lactonization as the key steps.

SUBMITTER: Bi J 

PROVIDER: S-EPMC11643441 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature