Gottingen Minipigs as a Model for Assessing the Impact of Drugs on the Gut and Milk Microbiota-A Preliminary Study.

ABSTRACT:

Background

Early gut microbiota (GM) dysbiosis can affect a child's health and has been linked to the onset of pathologies later in life. Breast milk is recognized as a major driver of the structure and dynamics of an infant's GM. In addition to nutritious and prebiotic compounds, milk contains a microbiota that is shaped by several maternal factors, including gut microorganisms and medications. However, the impact of the latter on the milk microbiota is still largely unknown. Here, we investigated the effects of amoxicillin on the milk microbiota and GM of lactating Göttingen Minipigs sows, a promising model for studying medication transfer during lactation.

Methods

Three sows were given amoxicillin (7 mg/kg/day) for three weeks starting from the second week after farrowing

SUBMITTER: Bencivenni S 

PROVIDER: S-EPMC11643497 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature