Novel Lipid-Based Carriers of Provitamin D₃: Synthesis and Spectroscopic Characterization of Acylglycerol Conjugated with 7-Dehydrocholesterol Residue and Its Glycerophospholipid Analogue.

ABSTRACT: The aim of this research was to design and synthesize new lipid conjugates of 7-DHC that could serve as a new storage form of esterified provitamin D₃, increasing the reservoir of this biomolecule in the epidermis and enabling controlled production of vitamin D₃ even during periods of sunlight deficiency. Acylglycerol and glycerophospholipid containing succinate-linked provitamin D₃ at the sn-2 position of the glycerol backbone were synthesized from dihydroxyacetone (DHA) and sn-glycerophosphocholine (GPC), respectively. The three-step synthesis of 1,3-dipalmitoyl-2-(7-dehydrocholesterylsuccinoyl)glycerol involved the esterification of DHA with palmitic acid, reduction of the carbonyl group, and conjugation of the resulting 1,3-dipalmitoylglyc

SUBMITTER: Gladkowski W 

PROVIDER: S-EPMC11643614 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature