Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base Complexes.

ABSTRACT: Four mononuclear bioefficient zinc coordination complexes [Zn(NN)₃](ClO₄)₂ (A-D) involving chiral bidentate Schiff base ligands have been synthesized and characterized by IR, ¹H, and ¹³C NMR spectroscopy and mass spectrometry. X-ray crystal structures of three of the zinc complexes revealed that the zinc metal ion is hexacoordinated, exhibiting a distorted octahedral geometry where both the nitrogen atoms (NN = pyridyl and imine) of imines are coordinated to the central zinc ion. The isolated zinc complexes were evaluated for their antimicrobial activity in vitro against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, displaying varying levels of growth inhibition. An acute toxici

SUBMITTER: Gutierrez Arguelles D 

PROVIDER: S-EPMC11643661 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature