The Oral Bioavailability of Vitamin B₁₂ at Different Doses in Healthy Indian Adults.

ABSTRACT:

Background/objectives

The bioavailability of crystalline vitamin B₁₂ (B₁₂) through active absorption is reported to have a maximum capacity of 1.5-2.5 µg per dose. A small passive bioavailability has also been suggested at high doses. The present study aimed to determine the dose-dependency of active B₁₂ absorption and to quantify its passive absorption at higher doses.

Methods

The dose-dependency of crystalline B₁₂ bioavailability was determined in nine healthy adults, using oral [¹³C]-cyanocobalamin, in a cross-over design at doses of 2.5, 5, and 10 µg. The dose order was randomised, with a washout of one month. Literature data from was added to the present study data in a meta-analysis of the relation between B₁₂

SUBMITTER: Kashyap S 

PROVIDER: S-EPMC11643782 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature