Optimization of Combined Ultrasound and Microwave-Assisted Extraction for Enhanced Bioactive Compounds Recovery from Four Medicinal Plants: Oregano, Rosemary, Hypericum, and Chamomile.

ABSTRACT: This study presents the synergistic application of ultrasound- and microwave-assisted extraction (UAE-MAE) as a novel and efficient method for recovering bioactive compounds from the medicinal plants oregano, rosemary, Hypericum perforatum, and chamomile. Extraction parameters, including microwave (MW) power, ultrasound (US) power, and extraction time, were optimized using the response surface methodology (RSM), with ethanol as the solvent. Extracts were evaluated for total phenolic content (TPC) via the Folin-Ciocalteu method and antioxidant activity (IC50) using the DPPH assay. High-performance liquid chromatography with diode array detection (HPLC-DAD) identified the main bioactive compounds contributing to their antioxidant and therapeutic potential. The optimized UAE-MAE condit

SUBMITTER: Laina KT 

PROVIDER: S-EPMC11643802 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature