Lipidomic Signature of Healthy Diet Adherence and Its Association with Cardiometabolic Risk in American Adults.

ABSTRACT:

Background

The aim of this study was to identify the blood lipidomic profile associated with a healthy eating pattern in a middle-aged US population sample and to determine its relationship with metabolic disorders and cardiovascular risk (CVR).

Methodology

Self-reported information about diet and blood samples were obtained from 2114 adult participants in the Midlife in the United States study (MIDUS). Food intake data were used to design a Healthy Diet Index (MIDUS-HEI) and to evaluate the predictive value by examining its association with health variables. The associated lipid signature (HEI-LS) was constructed using Lasso regression, from lipidomic data (LC/MS). Associations between HEI-LS, cardiometabolic biomarkers, and estimated CVR were assessed using multiple linear

SUBMITTER: Berkowitz L 

PROVIDER: S-EPMC11643808 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature