The Mediating Role of Body Mass Index in the Association Between Dietary Index for Gut Microbiota and Biological Age: A Study Based on NHANES 2007-2018.

ABSTRACT:

Objective

The dietary index for gut microbiota (DI-GM) is a newly proposed metric for assessing diet quality, and its relationship with biological age is unclear. We hypothesize that consuming foods conducive to a healthy gut microbiota environment may decelerate aging.

Methods

This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2007 to 2018. The DI-GM was calculated by averaging the intakes from two 24-h dietary recall interviews. The biological age indicators were assessed using the Klemera-Doubal Method (KDM), phenotypic age (PA), and homeostasis disorder (HD). Logistic regression, restricted cubic splines (RCS), and mediation analysis were employed to explore the association between DI-GM and KDM,

SUBMITTER: An S 

PROVIDER: S-EPMC11643866 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature