Bone Fracture Incidence in Postmenopausal Women: Results of a 10 Year Follow Up in a RAC-OST-POL Study of rs1544410, rs7975232 and rs731236 Polymorphisms.

ABSTRACT:

Background

The clinical significance of the genetic influence of vitamin D receptor polymorphisms has still not been well-analyzed.

Objectives

To verify whether rs1544410, rs7975232 and rs731236 polymorphisms are associated with a higher 10-year fracture risk in postmenopausal women.

Methods

The study group was a subset of a pre-defined population as part of the broader epidemiological research called the RAC-OST-POL Study and consisted of 358 postmenopausal women, chosen randomly from Racibórz (Poland) inhabitants (mean baseline age 65 ± 6.9 years, BMI 31.2 ± 5.5 kg/m²). From all participants' medical history, data concerning co-morbidities, fracture history, the medication used, parental history of bone fractures, cigarettes and alcohol use were taken at

SUBMITTER: Tabor E 

PROVIDER: S-EPMC11643942 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature