The Impact of Maternal Gestational Diabetes Mellitus on Minipuberty in Boys.

ABSTRACT:

Background/objectives

Minipuberty is thought to play an important role in the sexual maturation of infants. Maternal disorders during pregnancy were found to have an impact on the activity of the reproductive axis in the first year of life. This prospective, matched, cohort study was aimed at investigating whether the course of minipuberty in boys is affected by maternal gestational diabetes mellitus (GDM).

Methods

The study population consisted of three matched groups of boys: infants born to women with poorly controlled GDM, sons of women with adequately controlled GDM, and infants of healthy women with normal carbohydrate tolerance during pregnancy (control group). Salivary levels of testosterone, androstenedione, DHEA-S and estradiol, and urinary concentrations of FSH an

SUBMITTER: Kowalcze K 

PROVIDER: S-EPMC11644001 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature