Differential Effector Function of Tissue-Specific Natural Killer Cells against Lung Tumors.

ABSTRACT:

Introduction

Natural killer (NK) cells are innate lymphoid cells capable of directly killing target cells while modulating immune effector responses. Despite their multifunctional capacities, a limited understanding of their plasticity and heterogeneity has impeded progress in developing effective NK cell-based cancer therapies. In this study, we investigated NK cell tissue heterogeneity in relation to their phenotype and effector functions against lung tumors.

Methods

Using hanging drop tumor spheroid and subcutaneously established LL/2 (LLC1) lung tumor models, we examined NK cell receptor diversity and its correlation with tissue-specific cytotoxicity through multiparametric flow cytometry, fluorescence imaging, and cytotoxicity assays.

Results

We identified distin

SUBMITTER: Dunbar ZT 

PROVIDER: S-EPMC11644122 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature