The Deuterium Oxide Dilution Method to Quantify Human Milk Intake Volume of Infants: A Systematic Review-A Contribution from the ConcePTION Project.

ABSTRACT: Background: Global health organizations recommend breastfeeding, but maternal pharmacotherapy can disrupt this due to safety concerns. Physiologically based pharmacokinetic (PBPK) models predict medication transfer through breastfeeding, relying on validated milk intake volume data. However, the literature is mainly focused on different measurement methods, or such intake data have been collected without systematic review. This systematic review therefore aims to gather data on human milk intake volume derived using the (dose-to-the-mother) deuterium oxide dilution method, allowing for comparison with the literature. Additionally, it aims to explore the effects of maternal conditions on milk intake volume. Methods: PubMed, Embase, Web of science, Cochrane library, Scopus and

SUBMITTER: Cloostermans L 

PROVIDER: S-EPMC11644218 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature