A 11B-NMR Method for the In Situ Monitoring of the Formation of Dynamic Covalent Boronate Esters in Dendrimers.

ABSTRACT: The in situ monitoring of dynamic covalent macromolecular boronate esters represents a difficult task. In this report, we present an in situ method using fluoride coordination and ¹¹B NMR spectroscopy to determine the amount of boronate esters in a mixture of boronic acids and cis-diols. With fluoride coordination, the boronic acid and boronate esters afforded trifluoroborate and fluoroboronate esters, giving identical resonances at 3 and 9 ppm in the ¹¹B NMR spectra. The same titration did not alter the resonance of amine-coordinated boronate esters, which gave resonances of 14 ppm in the ¹¹B NMR spectra. Therefore, boronic acids, boronate esters, and amine-coordinated boronate esters gave three identical resonances, and the ratio of each component was obt

SUBMITTER: Yao YW 

PROVIDER: S-EPMC11644288 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature