In Situ Thermosensitive Mucoadhesive Nasal Gel Containing Sumatriptan: <i>In Vitro</i> and <i>Ex Vivo</i> Evaluations.

ABSTRACT: The aim of this study was to develop a thermosensitive mucoadhesive (MA) in situ nasal gel for sumatriptan. A 3D response surface methodology (Design of Expert version 11) was employed to formulate nine different formulations. The Pluronic F-127 concentration (X1) and chitosan concentration (X2) were selected as independent factors. The formulas were studied in terms of pH, clarity, drug content, gelation temperature, gelation time, gel strength, MA strength, viscosity, % release after 5 h, and release kinetics. The optimized formulas were studied for % permeated after 5 h and stability in addition to previous tests. The study of the stability of the optimized formula was performed under accelerated conditions (40 ± 2 °C, 75 ± 5% RH) for 3 months. The outcomes of the optimized formula were

SUBMITTER: Alshraim A 

PROVIDER: S-EPMC11644292 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature