Investigating the Relationship Between the Emulsification Parameters and Physical-Chemical Properties of Poly(D,L-lactic acid) Particles for Dermal Fillers.

ABSTRACT: Poly(L-lactic acid) (PLLA) and poly(D,L-lactic acid) (PDLLA) particles have been applied as dermal fillers for soft-tissue augmentation because they can induce foreign-body reactions, resulting in fibroblast proliferation and collagen formation. Although PLLA and PDLLA fillers are safe and biocompatible, clinical complications such as nodules and granulomas have been reported, possibly due to incomplete reconstitution. PDLLA particles were prepared via emulsification in this study, and three stirring speeds were investigated when adding PDLLA into carboxymethyl cellulose solution. The particle size, molecular weight of PDLLA, optical rotation, pH value, osmotic pressure, and reconstitution time were analyzed. A rabbit dorsal ear model was established to evaluate the soft-tissue augmentatio

SUBMITTER: Su CY 

PROVIDER: S-EPMC11644387 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature