Anti-Obesity Effects of <i>Pleurotus ferulae</i> Water Extract on 3T3-L1 Adipocytes and High-Fat-Diet-Induced Obese Mice.

ABSTRACT: This study offers promising insights into the anti-obesity potential of Pleurotus ferulae, an edible mushroom valued in Asian cuisine for its nutritional benefits. A hot water extract of P. ferulae (PWE) administered to high-fat diet-induced obese mice over an 8-week period significantly reduced their body weight gain and fat accumulation. PWE not only improved the body weight metrics but also positively influenced the serum lipid profile of obese mice by lowering their total cholesterol and low-density lipoprotein cholesterol levels. In vitro studies using 3T3-L1 adipocytes showed that PWE inhibited adipocyte differentiation and lipid accumulation by downregulating key adipogenic transcription factors, particularly PPARγ and C/EBPα, as well as related lipogenic genes involve

SUBMITTER: Hong S 

PROVIDER: S-EPMC11644537 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature