Optimization and Chemical Characterization of Extracts Obtained from Ferula persica var. latisecta Aerial Parts and Roots and Their Neuroprotective Evaluation.

ABSTRACT:

Background/objectives

The genus Ferula has been traditionally used for the treatment of various illnesses, but the potential of Ferula persica var. latisecta against different Alzheimer's disease (AD) hallmarks has never been achieved.

Methods

In this work, a pressurized liquid extraction (PLE) method was optimized to extract F. persica L. aerial parts and roots. Four different solvents (water, ethanol, ethyl acetate (EtAc), and cyclopentyl methyl ether (CPME)) were first tested, and the extraction yield, total phenolic content, reactive oxygen species scavenging capacity, and acetylcholinesterase (AChE) inhibition activity were evaluated.

Results

The results indicated that EtAc and CPME were the best solvents to be used, with the results o

SUBMITTER: Mohammadnezhad P 

PROVIDER: S-EPMC11644649 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature