Coinhibitory Effects of Resveratrol- and Protopanaxadiol-Enriched Rice Seed Extracts Against Melanogenic Activities in Melan-a Cells.

ABSTRACT: In the current study, we aimed to evaluate the combined antimelanogenic effects of resveratrol- and protopanaxadiol (PPD)-enriched rice seed extracts (DJ526 and DJ-PPD) in melan-a cells. The treatment antioxidant capacity was evaluated using the ABTS radical scavenging method. TR_3 (70% [wight (w)/w] of DJ526 and 30% [w/w] of DJ-PPD) markedly increased the antioxidant activity at a level similar to that of DJ526 and DJ-PPD alone. The antimelanogenic activities in melan-a cells were evaluated after co-culturing of treatments at the concentration of 100 μg/mL. The in vitro melan-a cell experiment showed that treatment with the DJ526 and DJ-PPD mixture significantly reduced the cellular tyrosinase activity and melanin content; suppressed the expression of melanogen

SUBMITTER: Monmai C 

PROVIDER: S-EPMC11644661 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature