In vivo functional significance of direct physical interaction between Period and Cryptochrome in mammalian circadian rhythm generation.

ABSTRACT: In the current model, the auto-negative feedback action of Period (Per) and Cryptochrome (Cry) on their own transcription is the hallmark mechanism driving cell-autonomous circadian rhythms. Although this model likely makes sense even if Per and Cry undertake this action in a mutually independent manner, many studies have suggested the functional significance of direct physical interaction between Per and Cry. However, even though the interaction is a biochemical process that pertains to the fundamentals of the circadian oscillator, its in vivo contribution to circadian rhythm generation remains undefined. To answer this question, we focused on zinc coordination between Per and Cry, whose contribution to circadian rhythm generation remains undefined. Specifically, we aimed to impair endoge

SUBMITTER: Kawabe J 

PROVIDER: S-EPMC11645128 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature