Aggressive Versus Moderate Fluid Replacement for Acute Pancreatitis: An Updated Systematic Review and Meta-Analysis.

ABSTRACT:

Background

A conservative strategy is the primary modality of treatment for acute pancreatitis of which fluid replacement is an important component. Since the results regarding early aggressive versus moderate fluid replenishment for acute pancreatitis are inconsistent, we sought to compare outcomes between the two resuscitation strategies in our meta-analysis.

Methods

We searched MEDLINE (PubMed), Embase, the Cochrane Library, and ClinicalTrials.gov for all available randomized controlled trials (RCTs) assessing outcomes for patients treated with aggressive fluid replacement compared to moderate fluid replacement. Our primary outcome was all-cause mortality.

Results

Our meta-analysis included 6 RCTs involving a total of 632 patients. Our results showed that aggressiv

SUBMITTER: Ehsan M 

PROVIDER: S-EPMC11645159 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature