Longitudinal Links between Changes in Body Composition and Liver Disease Severity in Children and Adolescents with Metabolic Dysfunction-Associated Steatotic Liver Disease.

ABSTRACT:

Objective

To investigate the relationship between longitudinal changes in body composition and liver disease severity in children with metabolic dysfunction-associated steatotic liver disease (MASLD).

Study design

This longitudinal, single-center, retrospective analysis included patients aged <20 years followed for MASLD who had had ≥2 bioelectrical impedance analyses (BIAs) performed. MASLD regression was defined as alanine aminotransferase (ALT) normalization or a decrease of >50% from baseline. Fat and skeletal muscle mass were adjusted for size by calculating respective indices (dividing by height²). Logistic and linear regressions were used to determine the independent relationship between changes in body composition over time and serological markers of liver

SUBMITTER: Speakman A 

PROVIDER: S-EPMC11645241 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature