Micro-DeMix: a mixture beta-multinomial model for investigating the heterogeneity of the stool microbiome compositions.

ABSTRACT:

Motivation

Extensive research has uncovered the critical role of the human gut microbiome in various aspects of health, including metabolism, nutrition, physiology, and immune function. Fecal microbiota is often used as a proxy for understanding the gut microbiome, but it represents an aggregate view, overlooking spatial variations across different gastrointestinal (GI) locations. Emerging studies with spatial microbiome data collected from specific GI regions offer a unique opportunity to better understand the spatial composition of the stool microbiome.

Results

We introduce Micro-DeMix, a mixture beta-multinomial model that deconvolutes the fecal microbiome at the compositional level by integrating stool samples with spatial microbiome data. Micro-DeMix facilitates the com

SUBMITTER: Liu R 

PROVIDER: S-EPMC11645251 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature