STRPsearch: fast detection of structured tandem repeat proteins.

ABSTRACT:

Motivation

Structured Tandem Repeats Proteins (STRPs) constitute a subclass of tandem repeats characterized by repetitive structural motifs. These proteins exhibit distinct secondary structures that form repetitive tertiary arrangements, often resulting in large molecular assemblies. Despite highly variable sequences, STRPs can perform important and diverse biological functions, maintaining a consistent structure with a variable number of repeat units. With the advent of protein structure prediction methods, millions of 3D models of proteins are now publicly available. However, automatic detection of STRPs remains challenging with current state-of-the-art tools due to their lack of accuracy and long execution times, hindering their application on large datasets. In most cases, manu

SUBMITTER: Mozaffari S 

PROVIDER: S-EPMC11645253 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature