Neuroprotective Effects of Dexamethasone in a Neuromelanin-Driven Parkinson's Disease Model.

ABSTRACT: Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra that primarily affects movement control. Neuroinflammation plays a pivotal role in driving the disease's progression. The persistent inflammatory state in the brain exacerbates neuronal damage, creating a cycle that perpetuates the neurodegenerative process. Glucocorticoids, such as dexamethasone, have potent anti-inflammatory properties and have been studied for their neuroprotective potential in different neurodegenerative diseases. However, their specific impact on PD remains unclear. This study aimed to evaluate the impact of dexamethasone on a neuromelanin (NM)-driven model of PD. We demonstrated that dexamethasone administration significantly improved motor function and p

SUBMITTER: Garcia-Gomara M 

PROVIDER: S-EPMC11645310 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature