Safety of flow-controlled ventilation with positive and negative end-expiratory pressure in a swine model of intracranial hypertension.

ABSTRACT:

Background

Patients with brain damage often require mechanical ventilation. Although lung-protective ventilation is recommended, the application of increased positive end-expiratory pressure (PEEP) has been associated with elevated intracranial pressure (ICP) due to altered cerebral venous return. This study investigates the effects of flow-controlled ventilation (FCV) using negative end-expiratory pressures (NEEP), on cerebral hemodynamics in a swine model of intracranial hypertension.

Methods

A model of intracranial hypertension involving bilateral trepan bolt holes was performed in 14 pigs. Pressure-controlled volume-guaranteed ventilation (PCV-VG) with PEEP and FCV using PEEP and then NEEP were applied. Intracranial pressure and oxygenation, as well as systemic hemodynam

SUBMITTER: Schranc A 

PROVIDER: S-EPMC11645394 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature