MMP9 in pan-cancer and computational study to screen for MMP9 inhibitors.

ABSTRACT:

Purpose

The stromal cell protein metalloproteinase 9 (MMP9), associated with extracellular matrix degradation and remodeling, promotes tumor invasion and metastasis and regulates cell adhesion molecule and cytokine activity. This study evaluated MMP9 in pan-cancer and screened for compounds and drug candidates that can inhibit it.

Methods

MMP9 expression in pan-cancer tissues was evaluated in a pan-cancer dataset from the University of California Santa Cruz database, along with the correlation between MMP9 and the tumor microenvironment (TME), RNA modification genes, and tumor mutation burden. MMP9 crystal structures were downloaded, and a ligand-based pharmacophore model was constructed. A machine learning model was constructed for further screening. The identified compound

SUBMITTER: Ai X 

PROVIDER: S-EPMC11645558 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature