Effect of body mass index on breast cancer prognosis: a focus on ER/PR status and subtype-specific recurrence risk.

ABSTRACT:

Objective

To explore prognostic differences in breast cancer (BC) recurrence risk across estrogen receptor (ER) and progesterone receptor (PR) defined subtypes, stratified by body mass index (BMI) categories, aiming to identify potential mechanisms.

Methods

A cohort of 358 breast cancer patients provided data on height, weight, menopausal status, and receptor profiles for analysis.

Results

Our findings highlighted that BMI's impact on BC prognosis was significantly influenced by ER/PR tumor status. In premenopausal women, BMI notably affected recurrence rates, especially in patients with ER-positive and PR-positive subtypes.

Conclusions

Adjusting treatment strategies based on BMI across different menopausal statuses and tumor subtypes could improve outcome for

SUBMITTER: Shen Q 

PROVIDER: S-EPMC11645606 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature