Cholecystectomy and blood lipid/glucose traits: insights from a population-based cross-sectional and Mendelian randomization study.

ABSTRACT:

Objectives

Cholecystectomy is noted for potentially impacting blood lipid/glucose levels, yet causal links remain unclear.

Methods

Cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 were employed to explore the relationship between cholecystectomy and blood lipid/glucose traits. Propensity-score matching (PSM) was performed to equalize baseline differences. Genome-wide association study (GWAS) data from the UK Biobank, FinnGen, Global Lipids Genetics Consortium (GLGC), and the Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) were analyzed by Mendelian randomization (MR) to infer causality. Combination of MR results was achieved with meta-analysis.

Results

Based on the NHANES database, significantly d

SUBMITTER: Wang YP 

PROVIDER: S-EPMC11645607 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature