Cistanche deserticola polysaccharide alleviates constipation by regulating intestinal barrier function and intestinal microbiota and their metabolites.

ABSTRACT: Constipation is a clinical condition characterized by reduced intestinal motility, dry and hardened stool, and prolonged retention. Common constipation medicines are less stable, and prolonged use can lead to dependency and side effects. Cistanche deserticola Ma, a well-known Traditional Chinese Medicine, is frequently used to alleviate constipation. In this study, we established a loperamide-induced constipation model in mice to investigate the effects of Cistanche polysaccharides (CDPS) and to explore its underlying pharmacological mechanism. The serum levels of inflammatory factors, gastrointestinal hormones and neurotransmitters of mice were measured by enzyme-linked immunosorbent assay (ELISA). Intestinal tight junction integrity was evaluated using immunohistochemistry,

SUBMITTER: Yu Z 

PROVIDER: S-EPMC11645619 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature