Resuscitation With Placental Circulation Intact Compared With Cord Milking: A Randomized Clinical Trial.

ABSTRACT:

Importance

Among preterm newborns undergoing resuscitation, delayed cord clamping for 60 seconds is associated with reduced mortality compared with early clamping. However, the effects of longer durations of cord clamping with respiratory support are unknown.

Objective

To determine whether resuscitating preterm newborns while keeping the placental circulation intact and clamping the cord after a long delay would improve outcomes compared with umbilical cord milking.

Design, setting, and participants

This randomized clinical trial (PCI Trial) was conducted at 8 Italian neonatal intensive care units from April 2016 through February 2023 and enrolled preterm newborns born between 23 weeks 0 days and 29 weeks 6 days of gestation from singleton pregnancies.

Intervention

SUBMITTER: Pratesi S 

PROVIDER: S-EPMC11645650 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature