Evaluation of mathematical models for predicting medicine distribution into breastmilk - considering biological heterogeneity.

ABSTRACT:

Introduction

A significant proportion of mothers take medication during the breastfeeding period, however knowledge of infant safety during continued breastfeeding is often limited. Breastmilk exhibits significant physiological heterogeneity, with a range of milk fat (creamatocrit), protein and pH values available within the literature. Mathematical models for the prediction of infant exposure are available and these predict that variable milk physiology will significantly affect accumulation of drugs within the breastmilk. These models are typically validated against limited datasets only, and to the best of our knowledge no widescale review has been conducted which accounts for the heterogeneity of breastmilk.

Methods

Observed area under the curve milk-to-plasma (M/P) rati

SUBMITTER: Heo S 

PROVIDER: S-EPMC11645658 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature