The relationship between anticholinergic burden and frailty in the year preceding a diagnosis of dementia with Lewy bodies.

ABSTRACT:

Introduction

Little is known regarding the relationship between anticholinergic medications and frailty in dementia with Lewy bodies (DLB).

Methods

Anticholinergic Cognitive Burden Scale (ACB) and Claims-based Frailty Index scores were calculated for 12 months prior to the dementia diagnosis using electronic medical record and claims data. Logistic regression was used to estimate the association between ACB and odds of frailty.

Results

Compared to controls (n = 525), a diagnosis of DLB (n = 175; adjusted odds ratio [aOR]: 15.1, 95% confidence interval [CI]: 7.0-33.9) or Alzheimer's disease (AD: n = 525; aOR = 7.7, 95% CI: 4.4-13.7) was associated with an increased odds of frailty. Patients with DLB had greater prescriptions for anticholinergic med

SUBMITTER: Wyman-Chick KA 

PROVIDER: S-EPMC11645712 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature