Sequential activity of CA1 hippocampal cells constitutes a temporal memory map for associative learning in mice.

ABSTRACT: Sequential neural dynamics encoded by time cells play a crucial role in hippocampal function. However, the role of hippocampal sequential neural dynamics in associative learning is an open question. We used two-photon Ca²⁺ imaging of dorsal CA1 (dCA1) neurons in the stratum pyramidale (SP) in head-fixed mice performing a go-no go associative learning task to investigate how odor valence is temporally encoded in this area of the brain. We found that SP cells responded differentially to the rewarded or unrewarded odor. The stimuli were decoded accurately from the activity of the neuronal ensemble, and accuracy increased substantially as the animal learned to differentiate the stimuli. Decoding the stimulus from individual SP cells responding differentially revealed that decision-m

SUBMITTER: Ma M 

PROVIDER: S-EPMC11645751 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature