HIV drug resistance following pre-exposure prophylaxis failure among key populations in sub-Saharan Africa: a systematic review and meta-analysis protocol.

ABSTRACT:

Background

Key populations (KP) are highly vulnerable to HIV acquisition and account for 70% of new infections worldwide. To optimize HIV prevention among KP, the World Health Organization recommends the combination of emtricitabine plus tenofovir disoproxil fumarate for pre-exposure prophylaxis (PrEP). However, PrEP failure could be attributed to drug resistance mutations (DRMs) but this is unexplored in sub-Saharan Africa (SSA).

Objectives

We aim to conduct a systematic review that will provide evidence on the prevalence of HIV drug resistance (HIVDR) following PrEP failure among KP in SSA.

Design

This will be a systematic review and meta-analysis of studies conducted in sub-Saharan Africa.

Methods and analysis

This systematic review will include randomized a

SUBMITTER: Ngoufack Jagni Semengue E 

PROVIDER: S-EPMC11645767 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature