Endogenous Levels of Circulating Androgens Are Not Associated with Risk of Microscopic Colitis.

ABSTRACT:

Background

Microscopic colitis is a chronic inflammatory disease that most commonly affects post-menopausal women. Exogenous hormone use has recently been linked with increased risk of microscopic colitis. Yet, it is unclear whether levels of endogenous sex hormones are also associated with risk of microscopic colitis.

Aim

To evaluate the association between prediagnostic plasma androgens and subsequent risk of microscopic colitis.

Methods

We conducted a case-control study nested within prospective cohort studies of the Nurses' Health Study (NHS) and NHSII. Cases of microscopic colitis were each matched to two controls according to age, cohort, menopause status, fasting status, and season of plasma collection. Prediagnosis plasma levels of androgens including dehydroe

SUBMITTER: Tracy MS 

PROVIDER: S-EPMC11645841 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature