Current status of serum metabolites biomarkers for polyps and colorectal cancer: a systematic review.

ABSTRACT:

Background

Early detection of colorectal cancer (CRC) is crucial to enhance the disease treatment and prognosis of patients. Colonoscopy remains the gold standard for CRC detection; however, it requires trained personnel with expensive tools. Currently, serum metabolites have been discovered to be used to discriminate patients with polyps and CRC. This study aimed to identify the most commonly detected predictive serum metabolites for polyps and CRC.

Methods

A systematic search of the Web of Science, PubMed, and Cochrane Library databases was conducted using PRISMA guidelines. Ten studies investigating serum metabolite biomarkers of CRC and polyps using different analytical platforms and study populations were included. QUADOMICS tool was used to analyse the quality of the i

SUBMITTER: Abu Bakar MF 

PROVIDER: S-EPMC11646065 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature