Circulating dimethylguanidino valeric acid, dietary factors, and risk of coronary heart disease.

ABSTRACT:

Aims

Circulating dimethylguanidino valeric acid (DMGV) was identified as a novel metabolite related to cardiorespiratory fitness and cardiometabolic abnormalities. Circulating DMGV levels are subjective to dietary modulation; however, studies on its associations with intakes of coronary heart disease (CHD)-related foods/nutrients are limited. We investigated whether plasma DMGV was related to risk of incident CHD. We tested associations of DMGV with CHD-related dietary intakes measured by 7-day dietary records and estimated corresponding disease risk.

Methods and results

This nested case-control study on the incidence of CHD included 1520 women (760 incident cases of fatal CHD and nonfatal myocardial infarction and 760 controls) from the Nurses' Health Study. Separately, pla

SUBMITTER: Heianza Y 

PROVIDER: S-EPMC11646101 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature